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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Bone Miner Res. 2012 Feb;27(2):331–341. doi: 10.1002/jbmr.549

Figure 3.

Figure 3

Effect of three amino acid changing variants in EIF2AK3.

(A) The location of three nonsynonymous SNPs on the protein. SP, signal peptide; TM, transmembrane domain. The diagram of the protein domains (*) was adapted from [16]. The conserved domains (**) were predicted by multiple sequence alignments in the NCBI Conserved Domain Database (http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?seqinput=NP_004827.4).

(B) Multispecies alignment of amino-acid sequences around three nonsynonymous SNPs, obtained from the UCSC genome browser.