Effect of three amino acid changing variants in EIF2AK3.
(A) The location of three nonsynonymous SNPs on the protein. SP, signal peptide; TM, transmembrane domain. The diagram of the protein domains (*) was adapted from [16]. The conserved domains (**) were predicted by multiple sequence alignments in the NCBI Conserved Domain Database (http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?seqinput=NP_004827.4).
(B) Multispecies alignment of amino-acid sequences around three nonsynonymous SNPs, obtained from the UCSC genome browser.