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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Bone Miner Res. 2012 Feb;27(2):331–341. doi: 10.1002/jbmr.549

Figure 4.

Figure 4

Activation of eIF2α signaling in lymphoblastoid cell lines with differing haplotypes.

(A) Lymphoblastoid cells homozygous for the common haplotype A (HapA) or for the low-BMD haplotype B (HapB) were untreated as control (Con.) or treated with indicated concentrations of TG for 15 minutes. Shown are the typical results of phosphorylated eIF2α, total eIF2α, and EIF2AK3, detected by Western blots with indicated antibodies. (B) Densitometric analysis of phosphorylated eIF2α (P-eIF2α) and total eIF2α (T-eIF2α) (n = 7 for each genotype). AU, arbitrary units. The basal levels were used as the correction for after treatment levels. (* P = 0.014)