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Distance traveled (cm) before or after single (upper panel) or repeated (10 mg/kg once daily for four consecutive days) M6G exposure (lower panel) in mice lacking mu opioid receptor (MOR−/−) and their wild-type littermates/control (MOR+/+). The data represent mean (±S.E.M.) of 5–6 mice per genotype for each experiment. *significantly different from the knockout mice (p<0.05); **significantly different from all other group (p<0.01)
