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. 2010 Oct 27;30(43):14513–14521. doi: 10.1523/JNEUROSCI.4025-10.2010

Figure 5.

Figure 5.

Maintenance of DRG identity requires BDNF. A, Injection of NGF (50 ng/ml) does not prevent the increase in migratory DRG neurons present in nav1.6 morphants (dashed black line). In contrast, injection of BDNF or NT-3 reduces the number of migratory DRG neurons in nav1.6 morphants to levels found in wild-type embryos (dotted black line). *p < 0.05, **p < 0.01 versus nav1.6 morphants without neurotrophin injection, Kruskal–Wallis test; sample size ranged between 28 and 63 embryos. B, Anti-BDNF injected at 48 hpf (white bars) increases the number of migratory DRG neurons in wild-type embryos. Conversely, injection of 10–500 ng/ml BDNF reduces the number of migratory DRG neurons in nav1.6 morphants. *p < 0.05, **p < 0.01 versus wild-type embryos injected with buffer only; + p < 0.05, ++ p < 0.01 versus nav1.6 morphants injected with buffer only; nonparametric Kruskal–Wallis test; sample size ranged between 13 and 34 embryos.