Table 1.

Optimization of ligand for the coupling of 7 with bromobenzene^a

Entry	Ligand		Yieldb
1		S-Phos	84% (75%)
2		RuPhos	76%
3		Me-Phos	31%
4		Dave-Phos	12%
5		Brett-Phos	47%
6		Dpe-Phos	30%

^aConditions: 1.0 equiv 7, 2.0 equiv PhBr, 2.0 equiv NaO^tBu, 2 mol % Pd₂(dba)₃, 4 mol % ligand, toluene (0.25 M), 110 °C.

^bYields were determined by ¹H NMR analysis of crude reaction mixtures using phenanthrene as an internal standard. The yield in parentheses is an isolated yield of pure product.