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. Author manuscript; available in PMC: 2013 Apr 23.
Published in final edited form as: Brain Res. 2012 Mar 1;1450:102–115. doi: 10.1016/j.brainres.2012.02.056

Figure 2. Increased caspase activity following treatment with reactive stimuli dB-cAMP or Aβ.

Figure 2

Treatment of neonatal astrocytes cultures with 1 mM dB-cAMP (dB) or 25 μM Aβ25–35 for 48 h significantly increased (A) total caspase activity and (B) levels of the active caspase-3 fragment as assessed by western blot (inset: representative western blot). Cultures treated for 24 h with the apoptotic stimulus 1μM staurosporine (STS) demonstrated the greatest increase in total caspase activity and levels of the active caspase-3 fragment. Data show mean levels (+SEM) from ≥ 3 independent experiments. * P < 0.01 relative to vehicle-treated control (Ctl).