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. Author manuscript; available in PMC: 2013 Apr 23.
Published in final edited form as: Brain Res. 2012 Mar 1;1450:102–115. doi: 10.1016/j.brainres.2012.02.056

Figure 4. Broad-spectrum caspase inhibition attenuates up-regulation of GS and FGF-2 expression in response to reactive stimuli, dB-cAMP and Aβ, in astrocyte cultures.

Figure 4

Neonatal astrocyte cultures were treated for 48 h with vehicle (Ctl), 1 mM dBcAMP (dB), or 25 μM Aβ25–35 in the absence (−) or presence (+) or 1 h pretreatment with 50 μM zVAD. Following the experiment, cultures were processed for western blot to assess levels of GS (A) and FGF-2 (C). β-Tubulin was assessed as to ensure equal protein loading. Relative protein levels of GS (B) and FGF-2 (D) were determined by densitometric scanning of western blots from ≥ 3 independent experiments. Data show mean values (+SEM) from each condition expressed as a percentage of the vehicle-treated control group. * P < 0.05 relative to matched (−) zVAD condition.