Fig. 3.

Schematic summary of hypothesized circuit-specific transcript alterations in pre- and postsynaptic markers of GABA neurotransmission in the DLPFC of subjects with schizophrenia. For each GABA_A α subunit, the background shading marks the cortical layers where the indicated change in expression of that subunit was found. The laminar specificity of the decrease in α1 expression matches that of the alterations in GAD67 and PV mRNAs thought to be present in PV+ basket cells. The increase in α2 expression in layer 2 is consistent with previous findings of pre- and postsynaptic alterations in chandelier cell inputs to the axon initial segment of pyramidal cells in this location. In contrast, the absence of alterations in α3 subunit expression, which is present postsynaptic to chandelier cells in deep layer pyramidal neurons matches the failure to find significant changes in chandelier cell inputs in these layers.

Adapted from Beneyto et al. (2010).