Table 2.
Risk of invasive breast cancer associated with rs8170 among white Europeans defined by ER, PR, and HER2 tumor status
| N | rs8170 | Ptrend | Case-only | |
|---|---|---|---|---|
| OR (95%CI) | Phet | |||
| ER Status | ||||
| Controls | 48,306 | 1.00 | --- | |
| ER+ | 25,649 | 0.99 (0.96 – 1.02) | 0.38 | 1.61 × 10−5 |
| ER− | 7,641 | 1.09 (1.05 – 1.14) | 6.69 × 10−5 | |
| PR Status | ||||
| Controls | 48,306 | 1.00 | --- | |
| PR+ | 19,996 | 0.99 (0.96 – 1.03) | 0.71 | 6.52 × 10−3 |
| PR− | 10,444 | 1.05 (1.01 – 1.10) | 7.39 × 10−3 | |
| ER/PR Status | ||||
| Controls | 48,306 | 1.00 | --- | |
| ER+/PR+ | 18,811 | 0.99 (0.96 – 1.02) | 0.60 | |
| ER+/PR− | 4,294 | 0.99 (0.93 – 1.05) | 0.66 | 3.68 × 10−4 |
| ER−/PR+ | 1,102 | 1.04 (0.93 – 1.16) | 0.47 | |
| ER−/PR− | 6,092 | 1.10 (1.05 – 1.16) | 4.10 × 10−5 | |
| ER, PR and HER2 Status | ||||
| Controls | 45,684 | 1.00 | --- | |
| (ER+ or PR+)/HER2− | 11,774 | 1.00 (0.97 – 1.04) | 0.80 | |
| (ER+ or PR+)/HER2+ | 1,918 | 1.02 (0.94 – 1.11) | 0.62 | 1.32 × 10−5 |
| ER−/PR−/HER2− | 2,216 | 1.21 (1.13 – 1.31) | 2.97 × 10−7 | |
| ER−/PR−/HER2+ | 1,109 | 0.94 (0.85 – 1.05) | 0.31 | |
OR, odds ratio; CI, confidence interval; ER, estrogen receptor; PR progesterone receptor; HER2, human epidermal growth factor receptor-2; +, positive; −, negative; Phet, Case-only heterogeneity p-value.