Figure 1.

cAMP-induced long-term synaptic potentiation at a monosynaptic CA3–CA1 cell pair in hippocampal slice cultures. (A) Paired recordings of presynaptic and postsynaptic cells were obtained from CA3 and CA1 regions, respectively, of a hippocampal slice culture. DG, dentate gyrus. A typical EPSP of a CA1 cell could be evoked by an action potential elicited in a synaptically connected CA3 cell. (B) Summary graph illustrating a long-lasting synaptic enhancement of EPSP amplitude (measured as percentage of the baseline) when Sp-cAMPS (50 μM, 15 min) was applied to the bath. Each point is the average of five experiments. Error bars indicate ± SEM.