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. 2001 Apr 10;98(9):5264–5269. doi: 10.1073/pnas.091093998

Figure 3.

Figure 3

Induction of cAMP-mediated LTP requires PKA and the late phase of LTP depends on protein synthesis. (A) Application of anisomycin (20 μM) blocked the late phase of Sp-cAMPS-induced LTP without affecting the early phase. Data are the average of four experiments. (B) Sp-cAMPS (50 μM) could not induce synaptic enhancement in slices treated with Rp-cAMPS (100 μM). (C) Summary of the effect of Sp-cAMPS (Sp) on synaptic transmission in slices treated with Rp-cAMPS (Rp) or anisomycin (aniso), compared with the control (pseudo perfusion). Values are percent changes in amplitude of EPSP measured at the early phase (40–60 min after Sp) and the late phase (100–120 min after Sp). *, P < 0.05; **, P < 0.01, compared with the respective control. (A–C) Error bars indicate ± SEM.