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. 2001 Apr 10;98(9):5264–5269. doi: 10.1073/pnas.091093998

Figure 4.

Figure 4

Effect of Sp-cAMPS on sEPSP. (A) Cumulative sEPSP amplitude distributions show that cAMP-mediated LTP is associated with significant increases in amplitudes of sEPSPs recorded both during the early phase (40–60 min after Sp, shaded line) and during the late phase (100–120 min after Sp, thin line), compared with the baseline (thick line). (B) Frequency of sEPSPs was increased during both early and late phases of LTP. *, P < 0.05, compared with the baseline. (C) No significant increase in the amplitude of sEPSPs was observed when Rp-cAMPS (Rp, 100 μM) was coapplied with Sp-cAMPS (50 μM). (D) Anisomycin (aniso, 20 μM) prevented the Sp-cAMPS-associated increase in the amplitude of sEPSPs. Error bars indicate ± SEM.