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. 2001 Apr 10;98(9):5264–5269. doi: 10.1073/pnas.091093998

Figure 5.

Figure 5

Sp-cAMPS induces phosphatase-dependent LTD in the presence of picrotoxin. (A) When slices were perfused with normal ACSF (control, ●, n = 5), LTD was induced after concurrent application of Sp-cAMPS (Sp) and picrotoxin (PTX, 20–50 μM). After slices were pretreated with 1 μM calyculin A (caly A) for 1 h, coapplication of Sp-cAMPS and picrotoxin no longer induced LTD (○, n = 3). (B) This form of LTD is accompanied by an increase in failure rate. (C) In the presence of anisomycin (aniso, 20 μM), Sp-cAMPS and picrotoxin did not produce LTD (n = 4). (D) Summary of data shown in A and C. Picrotoxin (PTX) applied alone did not cause significant depression (n = 4). *, P < 0.01, compared with the PTX group. Error bars indicate ± SEM.