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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2012 Mar 11;19(4):387–394. doi: 10.1038/nsmb.2245

Figure 7.

Figure 7

Mitotic TIF formation is dependent on Aurora B kinase but not on the SAC. (a) Schematic of the timing of experiments in panels b-d. (b) Quantification of MPM-2 positive IMR90 cells that were first treated with 1µM Velcade or 500 nM Taxol, then control-treated with DMSO, with Hesperadin (250nM), Aurora A inhibitor I (3 µM) or Reversine (0.5 µM). (c) Meta-TIF analysis of IMR90 cells treated as indicated in panel d. Quantification of γ-H2AX foci from panel c. Displayed as in Fig. 1e. Scale bar, 10 µm.