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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Skin Res Technol. 2011 Sep 14;18(2):225–231. doi: 10.1111/j.1600-0846.2011.00558.x

Figure 2. OCT image analyses and histology validation identify significant increases in the thickness of the epidermis in KC-Tie2 mice which decreases two weeks following doxycycline treatment.

Figure 2

Representative images taken with histology (A-B) and OCT (C-D) of KC-Tie2 mouse skin prior to beginning treatment (A, C) and 4 weeks following doxycycline treatment (B, D). Epidermal thickness measures using OCT and histology confirm untreated KC-Tie2 mice have significantly thicker epidermis than control mice (E). Following two weeks of doxycycline treatment, the increase in epidermal thickness is reversed as measured using OCT and is significantly decreased as measured histologically. Four weeks of doxycycline returns all epidermal thickness measures to similar levels in control and KC-Tie2 mice regardless of imaging modality. * p<0.05 compared to control animals.