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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Clin Cancer Res. 2012 Feb 9;18(7):1925–1935. doi: 10.1158/1078-0432.CCR-11-2941

Figure 4. The major CD4+Foxp3− population in TILs (non-Tregs) have reduced expression of CD127.

Figure 4

Papilloma tissues and PBMC were stained for CD4, CD25, CD127 and Foxp3 and analyzed by flow cytometry. A representative analysis of the expression of Foxp3 and CD127 on the CD4+ cells from papilloma tissue (A) and blood (B) from a patient with RRP are shown. Foxp3− “non-Tregs” are represented in the lower two quadrants. (C) The CD127 expression of CD4+ “non-Tregs” (lower two quadrants) in papilloma tissue (dashed line) and autologous blood (solid line). (D) Frequency of CD127low/− cells within the CD4+Foxp3− “non-Tregs” from the blood (22.2 ± 5.4%) and the tissue (49.2 ± 7.4 %) of 17 patients (p = <0.0001, two-tailed t-test). Expression of CD127 greater than that of Foxp3+cells was considered positive.