Table 1.

Information of critical genes in each of the four clusters

Cluster number	Function	Gene name
1	Pro-inflammatory Cytokine	IL1a
	Chemokine	Cxcl16, Ccl11, Ccl9
	Adaptive immune response regulation	Ceacam1
2	Unsaturated fatty acid biosynthesis	Acot1, Acot2, Acot3
	Fatty acid metabolism	Acaa2, Cpt1a, Dci
	Synthesis of ketone bodies	Hmgcs2
	Lipid metabolism and lipid transport	Eci1, Pigo, cyp4b1, Adfp, Pnpla8, Pank4, Crot, Etfdh
	Cell-cell junctions	Ablim3, Acer2, Cdh17
3	Complement and coagulation cascade	C2, C4bpa, C8a, Cfh, Masp1, Serping1
	N-glycan biosynthesis	B4galt1, Dad1, Ddost, Dpagt1, Ganab, Man1b1
	Ribosome	Rps25, Rps2
	Jak-STAT signaling	Il13, Il4, Il7, Jak3
	TLR4 signaling	IRAK1, LBP, TRAF3
	Anti-inflammatory cytokine	Il13, Il4
	Transcription	Brca1, Mcm7, Tcf25, Kdm1, Nfyb, Tef, Cited4, Otx1, Sox4, Acvr1, Tbx2, Zfhx2, Dmrt2, Tsc22d1, Ccdc 101
	Translation	Atpif1, Mrps21, Rps25, Rps2, Mrps11
	Protein folding	Dnajb11, Ppib, Hyou1, Edem2, Sep15, Pdia6, Dnajc3, Pdia3, Ugcgl1, Sec63, Mlec, Mecp2
	Protein degradation	Pcolce, Cpn1, caspase 12, Cdc34, Spink3, Hspa5, RGD1306508, Erlec1, Aph1a, Derl2, Os9, Rnf20, Ppp2r5c, Aurkaip1, Prss32, Prepl, Tbl1xr1, St14, P4hb
	Protein target	Tmed3, Ssr4, Tram1, Sec61a1, Rrbp1, Arfgap2, Gabarap, Erp29, Ssr3, Rrbp1, Sec61a1, Derl1, Gosr2, Cope, Tmed2, Copz1, Copg, Sec13, Abcb10, Kdelr1, Kdelr2, Tram1, Serp1, Ssr3, Atp6v0d1, Rabac1, Vps28
	Bile acid production	Idi1, tmem97, Npc2, Hsd17b4
4	Insulin signaling pathway	Gck, Irs1, Mknk2, Trip10
	Phenylalanine metabolism	Ddc
	Glycine, serine and threonine metabolism	Bhmt
	Galactose metabolism	Gck