Table 1.

Genome-wide screen of S. cerevisae collection of haploid deletion mutants for amiodarone-tolerant strains.

Functional categories	Mutants
Sphingolipid metabolism	ipt1, yor170w (overlapping lcb4), lcb4, sur1, csg2, ynl105w (overlapping inp52)
Nonsense-mediated mRNA decay pathway	nmd2, upf3, nam7
Transcriptional regulation	sip3, hap3
Programmed cell death pathway	ysp1, ysp2
Miscellaneous	sac6, ccs1, irc21, ymr102c, yor309c, orm2, mfa1, yor364w, ylr407w

Methods were as described by Gupta et al. (2003) in the screen for hypersensitive strains, except that 18 μM amiodarone was used. Wild type control failed to grow at this dose. Surviving strains are listed below. Note the enrichment of genes in lipid metabolism pathways, consistent with membrane effects of this drug.