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. 2010 Oct;10(8):617–624. doi: 10.2174/187152010794473975

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© 2010 Bentham Science Publishers Ltd

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. (2) — (A). Chemical structures of classical substrates of ABCC11. cAMP (cyclic adenosine monophosphate), cGMP (cyclic guanosine monophosphate), LTC₄ (leukotriene C₄), DNP-SG (S-(2,4-dinitrophenyl)-glutathione), E₁3S (estrone 3-sulfate), DHEAS (dehydroepiandrosterone 3-sulfate), and E₂17βG (estradiol 17-β-D-glucuronide). (B) Anticancer drugs that are transported by ABCC11. MTA (pemetrexed), MTX, (methotrexate), Ara-C (Cytosine arabinoside), PMEA (9’-(2’-phosphonyl-methoxyethyl)adenine) are substrate for ABCC11. 5-fluoro-2’-deoxyuridine 5’-monophosphate (FdUMP) is an active metabolite of 5-FU (5-fluorouracil) and transported by ABCC11.