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Anticancer drugs that regulate the expression of ABCC11. SAHA (suberoylanilide hydroxamic acid), one of the histone deacetylase inhibitors, induces the expression of ABCC11 mRNA. Estradiol reduces the expression of ABCC11 transcript in estrogen receptor-α-positive breast cancer cells, whereas TAM (tamoxifen), an estrogen receptor-α antagonist, abrogates the estrogen-mediated down-regulation effect.
