Table 2.
Comparison of hepatic fibrosis scoring systems between mild fibrosis and significant fibrosis regarding the hepatic histology of children with non-alcoholic fatty liver disease (mean ± SD)
| Parameters and hepatic fibrosis scores | Total (n = 77) | Mild fibrosis(stage 0-1) (n = 51) | Significant fibrosis(stage 2-3) (n = 26) | P value |
| Invasive histopathologic NAFLD scores1 | ||||
| Steatosis (grade 0/1/2/3) | 0/13/36/28 | 0/7/22/22 | 0/6/14/6 | 0.085 |
| Inflammation (grade 0/1/2/3) | 9/43/25/0 | 7/29/15/0 | 2/14/10/0 | 0.325 |
| Ballooning (grade 0/1/2) | 27/33/17 | 22/21/8 | 5/12/9 | 0.018 |
| NAS | 4.3 ± 1.4 | 4.18 ± 1.48 | 4.46 ± 1.14 | 0.470 |
| Noninvasive hepatic fibrosis scoring systems | ||||
| AST/ALT ratio | 0.53 ± 0.22 | 0.52 ± 0.16 | 0.57 ± 0.31 | 0.802 |
| AST/platelet ratio index | 0.71 ± 0.49 | 0.67 ± 0.54 | 0.78 ± 0.38 | 0.032 |
| PGA index | 3.78 ± 1.80 | 3.85 ± 1.89 | 3.68 ± 1.70 | 0.710 |
| Forns index | -0.94 ± 1.18 | -1.06 ± 0.21 | -0.69 ± 1.09 | 0.097 |
| FIB4 score | 0.27 ± 0.16 | 0.24 ± 0.12 | 0.31 ± 0.21 | 0.010 |
| NAFLD fibrosis score | -4.95 ± 1.32 | -5.07 ± 1.27 | -4.73 ± 1.41 | 0.532 |
| Pediatric NAFLD fibrosis index | 7.67 ± 2.48 | 7.71 ± 2.79 | 7.61 ± 2.08 | 0.314 |
1
Histopathologic non-alcoholic fatty liver disease (NAFLD) scoring on liver biopsy specimens was based on the definition by Kleiner et al[13]. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; NAS: Non-alcoholic fatty liver disease activity score.