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. Author manuscript; available in PMC: 2013 Mar 21.
Published in final edited form as: Bioconjug Chem. 2012 Mar 1;23(3):596–603. doi: 10.1021/bc200647q

Figure 2. The reactions and the structures of 1~17.

Figure 2

Reaction conditions: (a) CH2Cl2-H2O, pH 8~9, 50 °C, TBAB, N2, 5~6 hr, 92%(→4) or 86%(→5), respectively; (b) EtOH, AcOH (20 μL), benzoic hydrazide, nicotinic hydrazide or isoniazide (1.1 equiv.), 80°C, N2, 4~5 hr, 100%(→6), 90%(→7), 95%(→8), 95%(→9), 100%(→10) and 93%(→11) respectively; (c) 0.5M NH3-MeOH, 0°C→r.t., 24 hr, quantitative yields.