Table 4.
Effect of lipoatrophy on SF-8. Summary scores and item scores.
| Lipoatrophy |
||||||||
|---|---|---|---|---|---|---|---|---|
| SF-8 variables | n | Yes | n | no | p-value | Diff | Total pop. SD | CMD∗ |
| Physical component summary (PCS) | 190 | 40.58 | 832 | 45.17 | <0.0001 | 4.585 | 10.626 | 0.431 |
| Mental component summary (MCS) | 190 | 37.83 | 832 | 41.54 | 0.0001 | 3.714 | 11.973 | 0.310 |
| Daily activities (RE) | 195 | 38.23 | 862 | 41.90 | <0.0001 | 3.666 | 8.909 | 0.412 |
| Emotional affect (MH) | 198 | 38.56 | 866 | 41.40 | 0.0011 | 2.838 | 10.974 | 0.259 |
| Energy (VT) | 199 | 44.04 | 867 | 46.65 | 0.0004 | 2.612 | 9.205 | 0.284 |
| General health (GH) | 199 | 43.54 | 871 | 46.75 | <0.0001 | 3.213 | 8.565 | 0.375 |
| Pain (BP) | 199 | 42.20 | 859 | 45.87 | <0.0001 | 3.674 | 10.334 | 0.356 |
| Physical problems (PF) | 197 | 39.94 | 867 | 43.87 | <0.0001 | 3.936 | 9.250 | 0.426 |
| Social (SF) | 198 | 38.63 | 861 | 42.81 | <0.0001 | 4.172 | 9.948 | 0.419 |
| Work (RP) | 197 | 39.30 | 866 | 43.48 | <0.0001 | 4.181 | 10.064 | 0.415 |
Notes: ∗CMD = Clinically meaningful differences. Patients with lipoatrophy had worse HRQL in both summary scores and in all eight individual questions, with the clinically meaningful differences ranging from 0.259–0.431 (small to medium)