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. 2011 Nov 18;18(1):231–243. doi: 10.2119/molmed.2011.00210

Figure 4.

Figure 4

In vivo antenatal PD-123319 treatment effects on lung growth. (A) Ratio of left, right and total lung-to-body weight in control (C), nitrofen (N) and CDH groups treated with saline (C + S, N + S, CDH + S) or PD-123319 (C + PD, N + PD, CDH + PD). Antenatal administration of PD-123319 enhanced lung growth in all studied groups. (B) Effect of PD-123319 treatment on left, right and total lung hypoplasia. Prenatal administration of PD-123319 ameliorated both left and right lung hypoplasia. Results are expressed as %. P < 0.001: *versus C + S, †versus N + S, ‡versus CDH + S, llversus C + PD, §versus N + PD. For left lung, there is a statistically significant interaction between variables: disease–treatment (P = 0.009).