Table 1.
The signaling proteins and their activities in different cells.
| Signaling | Cell type | Activity | Reference |
|---|---|---|---|
| PKA | RAW264, J774, MPM | ABCA1 mRNA↑ | 46–48 |
| Fibroblasts, CHO, BHK, RAW264, Human embryonic kidney cells, 293T, Flip-In 293 cells, HeLa cells, THP-1 | ABCA1 phosphorylation↑ | 49–52 | |
| PKC | WI-38, HEK293 | ABCA1 protein stability↑ | 53 |
| COS-1, HEK293, HepG2 | ABCA1 mRNA↓ | 54 | |
| JAK2 | BHK | ABCA1 activity↑, apoA-I binding↑ | 25,55,56 |
| J774, BHK | STAT3↑ | 57 | |
| Rho GTPases | Fibroblasts, HEK293 | Cdc42↑, ABCA1 activity↑ | 58–60 |
| HEK293, THP-1 | RhoA↑, ABCA1 protein stability↑ | 24 | |
| Ca2+ | BALB/3T3, THP-1, BHK, RAW 267.4 | ABCA1 protein stability↑ | 61,62 |
↑, Increased expression, enhanced activity or effect; ↓, decreased expression, inhibited activity or effect.