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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Nat Methods. 2011 Oct 28;8(11):919–931. doi: 10.1038/nmeth.1735

Figure 1.

Figure 1

NMR techniques and site-specific probes for characterizing motional modes that carry RNA structure along various regions of the dynamic structure landscape. Dynamic Structure Landscape: Transition free energies (red, kcal/mol) corresponding to typical timescales of interconversion were estimated using transition state theory at 25 °C. NMR Experiments: Solid lines indicate the timescales at which each NMR experiment is optimally suited for, while the dotted lines indicate timescales that are difficult to probe. Probes: Nuclei most commonly used for RNA dynamics measurements: protonated carbons (blue), imino protons (green), backbone phosphorus (red).