Table 1.
Selected Trp53-regulated genes in a gene array analyses of OSE cells
| Gene symbol | Pten/Kras (Trp53+)/WT | Pten/Kras (Trp53−)/WT |
|---|---|---|
| Cell cycle/apoptosis | ||
| Ccnd1 | 4.4 | 2.9 |
| Cdkn1a(p21)a | 1.9 | −2.1 |
| Cdkn2a(p16)a | −1.0 | 27.9 |
| Cdkn2b(p15) | −23.2 | 1.1 |
| Igfbp2 | −246.1 | −1.3 |
| Igfbp6b | −.3 | 1.3 |
| Igfbp7b | −11.8 | −1.6 |
| Mdm2a | 6.3 | 1.3 |
| Mki67(Ki67) | 4.5 | 1.7 |
| Pcnaa | 4.0 | 1.4 |
| Pdzd2b | −31.5 | −1.6 |
| Trp53b | 1.2 | −3.3 |
| DNA stability/repair | ||
| Birc5 | 10.7 | 3.1 |
| Brca1 | 10.1 | 2.7 |
| Hellsa | 13.5 | 2.5 |
| Hmgb2 | 6.6 | 2.2 |
| Mcm6 | 4.2 | 1.6 |
| Mcm7 | 4.6 | 1.2 |
| Mcm10 | 7.8 | 1.6 |
| Mdm2 | 6.3 | 1.3 |
| Rad51a | 13.4 | 2.6 |
| Metastasis/motility | ||
| Cadm4 | −9.0 | 1.3 |
| Capn2b | 1.3 | 1.2 |
| Cd200b | −22.1 | 2.3 |
| Cd44 | 2.6 | 2.2 |
| Perpa | 32.7 | 1.7 |
| Tubb3 | 26.2 | 1.3 |
| Stem cell-like | ||
| Cd24a | 35.8 | 1.5 |
| Ly6a | 56.8 | −1.0 |
| Thy1 | −15.4 | 1.9 |
| Transcription factors | ||
| Areg | 13.5 | −1.6 |
| Egr1b | −25.1 | −2.5 |
| Esr1 | −39.3 | −1.6 |
| Eya4b | 22.9 | −1.0 |
| Irx3b | −6.9 | 1.1 |
| Pgr | −4.6 | −1.9 |
| Tumor suppressors | ||
| Armcx1 | −3.1 | −1.2 |
| Armcx2 | −11.6 | −1.7 |
| Cd82 | −6.1 | 1.1 |
| Pdzd2 | −31.5 | −1.6 |
| Tshz2 | −23.1 | −1.2 |
| Uhrf1b | 11.8 | 2.7 |
WT, Wild type.
a
P53 target genes.
b
Genes expressed in human low-grade serous ovarian carcinomas.