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Basal and stimulated aldosterone (A), cortisol (B), and 18-oxocortisol (C) production by HAC15 infected with control or KCNJ5 T158A lentiviruses. Cells were incubated for 24 h with no secretagogue or 10 nm of either A-II or 10 μm forskolin. *, P < 0.01 vs. each control, n = 4. †, P < 0.01 vs. aldosterone levels after A-II stimulation in KCNJ5–T158A cells (n = 4).
