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MR antagonism with canrenoic acid had no effect on MAP (A) or HR (B) in rats fed the HF diet. MAP and HR were measured by telemetry, the results shown are for the last week of the study. Results were analyzed by one-way ANOVA (P = 0.03 for MAP and 0.03 for HR) (n = 7 for control, n = 6 for HF, and n = 7 for HF+CAN; * indicates a significant difference from control after Bonferroni correction).
