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Rats fed the HF diet exhibited MRA remodeling as evidenced by an increase in the vessel wall thickness (A) and the wall-lumen ratio (B). Canrenoic acid treatment prevented the vessel remodeling as assessed by pressure myography under zero flow and calcium-free conditions (n = 7 for control, n = 7 for HF, and n = 8 for HF+CAN; * indicates a significant difference by two-way repeated-measures ANOVA).
