Fig. 2.

KP-54 in vivo from the S-ME/MBH of ovarian intact prepubertal (A and B) and pubertal (C and D) monkeys. Samplings during the morning (A and C) and during the evening (B and D) are shown by open bars and closed bars, respectively, at the top of each graph. KP-54 release occurs in a pulsatile manner in both prepubertal (morning in A and evening in B) and pubertal (morning in C and evening in D) monkeys. Note that the scale of the y-axis in C and D (pubertal monkeys) is 10-fold higher than that in A and B (prepubertal monkeys). The IPI and the pulse amplitude in prepubertal monkeys are longer and lower, respectively, compared with those in pubertal monkeys. Asterisks indicate peaks as determined by PULSAR.