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. 2001 Apr 24;98(9):5300–5305. doi: 10.1073/pnas.091039298

Figure 3.

Figure 3

Lack of cocaine-conditioned place preference in DAT knockout mice with no or one copy of the SERT gene. (Upper) Conditioned place preference induced by 10 mg/kg of cocaine in mice of several genotypes (n, 8–56). Time scores shown represent differences between post- and preconditioning time spent in the cocaine-paired environment. DAT knockout mice with no or one copy of SERT displayed no preference for the places associated with 10 mg/kg of cocaine. *, P < 0.05 vs. saline. Average initial preference for the nonpreferred side for all groups was between 37 and 45%. (Lower) Conditioned place preference induced by 10- and 20-mg/kg of cocaine doses in mice of several genotypes (n, 8–56). Time scores shown represent differences between post- and preconditioning time spent in the cocaine-paired environment. Wild-type mice and SERT knockout mice with one copy of DAT displayed significant preferences for the place associated with either 10 or 20 mg/kg of cocaine, but double knockout mice did not have a significant preference for places associated with either dose. *, P < 0.05 vs. saline.