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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Future Med Chem. 2012 Mar;4(3):289–296. doi: 10.4155/fmc.11.185

Figure 2. Simplified coagulation pathway showing the different points at which heparin, low and ultralow MW heparins inhibit coagulation through anti-thrombin III.

Figure 2

The arrows indicate the direction of the coagulation cascade (from activation to fibrin clot formation). The lines passing through AT show the points in the pathway inhibited by heparin, low and ultralow MW heparins through their interactions with AT. The thinner line passing through AT indicates the low level of thrombin inhibition by low MW heparins. AT: Anti-thrombin III; LMWH: Low MW heparin; ULMWH: Ultralow MW heparin.