Figure 1.
Histograms depicting paw withdrawal thresholds (mean ± SEM) elicited by applying von Frey monofilaments to the planter surface of the hindpaw. Mice of both genders harboring the disrupted Gabrb3 gene on either the maternal (p+/m−) or paternal (p−/m+) chromosomal allele were tested for mechanical sensitivity. Female +/+, n=14; female p+/m−, n=16; female p−/m+, n=18. Male +/+, n=15; male p+/m−, n=14; male p−/m+, n=14. *p<0.05, ***p<0.001 represents difference from gender-matched controls; ##p<0.01 represents difference between male p+/m− and p−/m+ mice.