Table 3.
Impact of potential prognostic factors on DFS of patients of lung adenocarcinoma in all stage by univariate and multivariate analysis
| No. | % | Univariate analysis |
Multivariate analysis | |||
|---|---|---|---|---|---|---|
| P value | Hazard ratio | 95% CI | P value | |||
| Total | 559 | |||||
| Age | ||||||
| < 65 | 213 | 38 | 0.388 | 1.000 | ||
| ≥ 65 | 346 | 62 | 1.933 | 0.849-4.402 | 0.116 | |
| Gender | ||||||
| Female | 288 | 52 | 0.768 | 1.000 | ||
| Male | 271 | 48 | 0.807 | 0.232-2.803 | 0.735 | |
| Smoking status | ||||||
| Non-smoker | 284 | 49 | 0.560 | 1.000 | ||
| Smoker | 275 | 51 | 1.164 | 0.342-3.956 | 0.808 | |
| Tumor size | ||||||
| < 30 mm | 396 | 71 | 0.059 | 1.000 | ||
| ≥ 30 mm | 163 | 29 | 0.819 | 0.338-1.985 | 0.658 | |
| Pathological stage | ||||||
| I | 458 | 82 | <0.001 | 1.000 | ||
| II, III, IV | 101 | 18 | 2.768 | 1.113-6.884 | 0.028 | |
| Pleural invasion | ||||||
| Negative | 452 | 81 | <0.001 | 1.000 | ||
| Positive | 107 | 19 | 0.848 | 0.345-2.083 | 0.719 | |
| Lymphatic invasion | ||||||
| Negative | 466 | 83 | <0.001 | 1.000 | ||
| Positive | 93 | 17 | 3.430 | 1.363-8.634 | 0.009 | |
| Vascular invasion | ||||||
| Negative | 427 | 76 | <0.001 | 1.000 | ||
| Positive | 132 | 24 | 3.309 | 1.312-8.350 | 0.011 | |
| SMPC | ||||||
| Negative | 540 | 97 | <0.001 | 1.000 | ||
| Positive | 19 | 3 | 1.871 | 0.528-6.630 | 0.332 | |
| AMPC | ||||||
| Negative | 460 | 83 | 0.045 | 1.000 | ||
| Positive | 99 | 17 | 1.132 | 0.450-2.845 | 0.792 | |
DFS, disease free survival; No., number of patients; SMPC, stromal micropapillary component; AMPC, aerogeneous micropapillary component; CI, confidence interval.