Table 4.
Impact of potential prognostic factors on DFS of patients of lung adenocarcinoma in p-stage I by univariate and multivariate analysis
| No. | % | Univariate Analysis |
Multivariate analysis | |||
|---|---|---|---|---|---|---|
| P value | Hazard ratio | 95% CI | P value | |||
| Total | 458 | |||||
| Age | ||||||
| < 65 | 172 | 38 | 0.394 | 1.000 | ||
| ≥ 65 | 286 | 62 | 2.191 | 0.474-10.131 | 0.316 | |
| Gender | ||||||
| Female | 249 | 54 | 0.063 | 1.000 | ||
| Male | 209 | 46 | 0.157 | 0.014-1.787 | 0.136 | |
| Smoking status | ||||||
| Non-smoker | 248 | 54 | 0.204 | 1.000 | ||
| Smoker | 210 | 46 | 0.768 | 0.117-5.052 | 0.784 | |
| Tumor size | ||||||
| < 30 mm | 358 | 78 | 0.264 | 1.000 | ||
| ≥ 30 mm | 100 | 22 | 0.304 | 0.037-2.504 | 0.268 | |
| Pleural invasion | ||||||
| Negative | 402 | 88 | < 0.001 | 1.000 | ||
| Positive | 56 | 12 | 1.519 | 0.328-7.040 | 0.593 | |
| Lymphatic invasion | ||||||
| Negative | 415 | 91 | < 0.001 | 1.000 | ||
| Positive | 43 | 9 | 5.016 | 1.295-19.434 | 0.020 | |
| Vascular invasion | ||||||
| Negative | 390 | 85 | < 0.001 | 1.000 | ||
| Positive | 68 | 15 | 4.494 | 1.006-20.081 | 0.049 | |
| SMPC | ||||||
| Negative | 448 | 98 | < 0.001 | 1.000 | ||
| Positive | 10 | 2 | 9.028 | 1.164-70.031 | 0.035 | |
| AMPC | ||||||
| Negative | 389 | 98 | 0.023 | 1.000 | ||
| Positive | 69 | 2 | 1.825 | 0.378-8.808 | 0.454 | |
DFS, disease free survival; No., number of patients; SMPC, stromal micropapillary component; AMPC, aerogeneous micropapillary component; CI, confidence interval.