Table 5.
Staining Scores in SMPC, AMPC and nMPC lesions
| Classification/Antibody | SMPC | AMPC | nMPC |
|---|---|---|---|
| Cellular adhesion molecules | |||
| E-cadherin | 215.3* | 143.9 | 187.1 |
| CD44 | 60.8‡ | 205.9¶ | 141.3 |
| Laminin5γ2 | 69.4 | 36.9 | 60.3 |
| Growth factor | |||
| VEGF-C | 294.4 | 296.4 | 282.1 |
| Apoptosis-associated proteins | |||
| bcl2 | 13.2 | 11.1 | 21.8 |
| p53§ | 36.4 | 26.1 | 45.0 |
| cleaved caspase-3§ | 0.3 | 0.2 | 0.4 |
| Mucin-related proteins | |||
| MUC1 | 169.7 | 182.5 | 202.1 |
| MUC6 | 0.0 | 0.0 | 0.0 |
| Hypoxia induced protein | |||
| HIF-1α | 1.8 | 2.4 | 2.9 |
| Others | |||
| TTF-1 | 267.9 | 289.3 | 248.6 |
| SP-A | 45.2‡ | 82.6 | 123.2 |
| Vimentin | 112.1 | 117.9 | 72.1 |
| Ki-67§ | 22.6 | 16.9 | 16.2 |
| LYVE1 | 98.9 | 107.2 | 101.9 |
| c-Met | 217.2 | 253.8 | 211.4 |
| Phospho-c-Met | 34.2‡ | 50.0 | 88.0 |
SMPC, stromal micropapillary component; AMPC, aerogeneous micropapillary component; nMPC, non-micropapillary component; VEGF-C, vascular endothelial growth factor-C; HIF-1α, hypoxia induced factor 1-α; TTF-1, thyroid transcription factor-1; SP-A, surfactant apoprotein A; LYVE1, lymphatic vessel endothelial hyaluronan receptor 1.
§ Positivity rate of positive tumor cells in 300 tumor cells (percentage).
* The difference in staining scores between SMPC and AMPC is statistically significant (P = 0.020).
‡ The differences in staining scores between SMPC and nMPC are statistically significant for CD44 (P = 0.011), and SP-A (P = 0.024) and phospho-c-Met (P = 0.011) expression.
¶ The difference in staining scores between AMPC and nMPC is statistically significant (P = 0.015).