Table 1.
Type of IDH1 and IDH2 mutations identified in 230 AML patients
| Mutation | Nucleotide change | Predicted protein change | No. of patients |
|---|---|---|---|
| IDH1* | |||
| c.G395A | CGT-CAT | p.R132H | 8 |
| c.C394T | CGT-TGT | p.R132C | 6 |
| c.C394A | CGT-AGT | p.R132S | 2 |
| c.C394G | CGT-GGT | p.R132G | 2 |
| c.G395T | CGT-CTT | p.R132L | 1 |
| c.A297G | ATA-ATG | p.I99M | 1 |
| IDH2** | |||
| c.G419A | CGG-CAG | p.R140Q | 20 |
| c.G515A | AGG-AAG | p.R172K | 4 |
Abbreviation: AML, acute myeloid leukemia; C, cysteine; G, glycine; H, histidine; I, isoleucine; K, lysine; L, leucine; M, methionine; Q, glutamine; S, serine
*IDH1 nucleotide numbering based upon the National Center for Biotechnology Information sequence NM_005896.2
**IDH2 nucleotide numbering based upon the National Center for Biotechnology Information sequence NM_002168.2