Table 2.
Characteristics of AML patients with a wild type or mutated IDH1
| Variable | All cases | IDH1m | IDH1wt | P* |
|---|---|---|---|---|
| No. of cases | 230 | 20 | 210 | |
| No. of males/females | 101/129 | 5/15 | 96/114 | .058 |
| Age, years | .860† | |||
| Median (range) | 44 (13-86) | 42.5 (15-85) | 45 (13-86) | |
| Hemoglobin, g/dL | .311† | |||
| Median (range) | 7.8 (1.4 -14.5) | 7.4 (2.9 - 10.8) | 7.85(1.4-14.5) | |
| WBC count, x109/L | .323† | |||
| Median (range) | 27.7 (0.6 -494.4) | 26.9 (1.0 -190.9) | 27.7 (0.6 -494.4) | |
| Platelet, x109/L | .923† | |||
| Median (range) | 46 (1.8-965) | 56 (16.9 - 386) | 45.5 (1.8-965) | |
| Percentage of blasts | .738† | |||
| Median (range) | 70.19 (6.69-95.44) | 75.8 (13.3-91.4) | 69.77 (6.69-95.44) | |
| Patients (%) | Patients (%) | |||
| FAB classification | ||||
| M0 | 3 | 1 (5) | 2 (0.9) | |
| M1 | 51 | 1 (5) | 50 (23.8) | |
| M2 | 76 | 13 (65) | 63 (30) | |
| M3 | 36 | 5 (25) | 31 (15) | |
| M4 | 34 | 0 (0) | 34 (16) | |
| M5 | 21 | 0 (0) | 21 (10) | |
| M6 | 8 | 0 (0) | 8 (3.8) | |
| M7 | 1 | 0 (0) | 1 (0.5) | |
| Patients (%) | Patients (%) | |||
| Cytogenetics | ||||
| Abnormal | ||||
| t(15;17) | 36 | 5 (25) | 31 (15) | .184 |
| t(8;21) | 20 | 0 (0) | 20 (10) | .149 |
| inv(16) | 3 | 0 (0) | 3 (1) | .760 |
| trisomy 8 | 4 | 1 (5) | 3 (1) | .307 |
| Other trisomies | 7 | 0 (0) | 7 (3) | .524 |
| All others including monosomies, deletions or combination of these | 22 | 2 (10) | 20 (10) | .594 |
| Complex karyotype | 8 | 0 (0) | 8 (4) | .477 |
| Normal | 126 | 11 (55) | 115 (55) | .587 |
Abbreviation: IDH1m, IDH1 mutated; IDH1wt, IDH1 wild type
* Fisher exact test unless otherwise indicated; †, the student t- test