Table 3.
Characteristics of AML patients with a wild type or mutated IDH2
| Variable | All cases | IDH2m | IDH2wt | P* |
|---|---|---|---|---|
| No.of cases | 230 | 24 | 206 | |
| No.of males/females | 101/129 | 11/13 | 90/116 | .504 |
| Age, years | .001† | |||
| Median (range) | 44 (13-86) | 49.5 (38-80) | 43 (13-86) | |
| Hemoglobin, g/dL | .059† | |||
| Median (range) | 7.8 (1.4 - 14.5) | 9.25 (4.7-12.6) | 7.7 (1.4 - 14.5) | |
| WBC count, × 109/L | .789† | |||
| Median (range) | 27.7 (0.6 - 494.4) | 29.73 (0.89-222) | 26.4 (0.6 - 494.4) | |
| Platelet, x109/L | .048† | |||
| Median (range) | 46 (1.8-965) | 59 (11-965) | 45 (1.8-852) | |
| Percentage of blasts | .133 † | |||
| Median (range) | 70.19 (6.69-95.44) | 61.79 (32.52-95.03) | 71.66 (6.69-95.44) | |
| Patients (%) | Patients (%) | |||
| FAB classification | ||||
| M0 | 3 | 0 (0) | 3 (1.5) | |
| M1 | 51 | 1 (4) | 50 (24) | |
| M2 | 76 | 11 (46) | 65 (31) | |
| M3 | 36 | 6 (25) | 30 (15) | |
| M4 | 34 | 6 (25) | 28 (14) | |
| M5 | 21 | 0 (0) | 20 (10) | |
| M6 | 8 | 0 (0) | 8 (4) | |
| M7 | 1 | 0 (0) | 1 (0.5) | |
| Patients (%) | Patients (%) | |||
| Cytogenetics | ||||
| Abnormal | ||||
| t(15;17) | 36 | 6 (25) | 30 (14.6) | .150 |
| t(8;21) | 20 | 1 (4.2) | 19 (9.2) | .355 |
| inv(16) | 3 | 0 (0) | 3 (1.5) | .717 |
| trisomy 8 | 4 | 1 (4.2) | 3 (1.5) | .358 |
| Other trisomies | 7 | 2‡ (8.2) | 5 (2.4) | .158 |
| All others including monosomies, deletions or combination of these | 22 | 1 (4.2) | 21 (10.2) | .301 |
| Complex karyotype | 8 | 0 (0) | 8 (3.8) | .408 |
| Normal | 126 | 12 (50) | 114 (55.3) | .388 |
Abbreviation: IDH2m, IDH2 mutated; IDH2wt, IDH2 wild type
* Fisher exact test unless otherwise indicated; †, Student t- test; ‡, 2 cases of trisomy11 harboring IDH2 R172K mutation