Table 2. Gonad phenotype in E14.5–16 Wt1+/− and Sf1+/− XY fetuses.
E14.5–16 XY gonads | ||||||
Maternalgenotype | Paternalgenotype | +/−Ovaries | +/− Ovotestes | +/−Testes | +/− Abnormaltestesa | Total +/− XY gonads |
B6 +/+ | B6 Wt1+/− XYB6 | 0 (0%) | 0 (0%) | 28 (100%) | 0 (0%) | 28 |
B6 Wt1+/− | B6 +/+ XYAKR | 5b (10%) | 23 (48%) | 8 (17%) | 12 (25%) | 48 |
B6 Wt1+/− | D2 +/+ XYAKR | 0 (0%) | 0 (0%) | 24 (100%) | 0 (0%) | 24 |
D2 Wt1+/− | B6 +/+ XYAKR | 0 (0%) | 0 (0%) | 12 (100%) | 0 (0%) | 12 |
B6 +/+ | B6 Sf1+/− XYB6 | 0 (0%) | 0 (0%) | 20 (100%) | 0 (0%) | 20 |
B6 Sf1+/− | B6 +/+ XYAKR | 31 (91%) | 3 (9%) | 0 (0%) | 0 (0%) | 34 |
D2 Sf1+/− | B6 +/+ XYAKR | 0 (0%) | 0 (0%) | 14 (100%) | 0 (0%) | 14 |
Cord development is somewhat delayed at the anterior and/or posterior ends but the gonad is not an obvious ovotestis.
Two were abnormally shaped but no testicular cords were evident.