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. 2012 Apr 5;7(4):e33920. doi: 10.1371/journal.pone.0033920

Figure 1. Generation of Ad5 vectors with chimeric hexons derived from Ad2, Ad43 and Ad34.

Figure 1

A schematic view of the Ad5 hexon protein and viable chimeric vectors is shown. The positions of surface loops (DE1 and FG1) within the hexon protein are indicated. The HVRs 1–9, indicated in black, are shown above the Ad5 hexon. Sequences from Ad5 are indicated in white, Ad2 in diagonal stripes, Ad34 in gray and Ad43 in black. Viable vectors produced were: Ad5H(5–5) containing the wild-type Ad5 hexon; Ad5H(2–2) containing the Ad2 DE1 and FG1 loops; Ad5H(5–43) containing the FG1 loop from Ad43; and Ad5H(5–34) containing the FG1 loop from Ad34.