Table 5.

SAR around hit series 2 a.

Compd	R	TbTryS IC50 [μm]
36	2-thiophene	8.5
37	5-(2,4-dimethylthiazole)	2.2
38	4-(1,3,5-trimethylpyrazole)	2.6
39	1-naphthyl	>100
40	2,5-dimethoxyphenyl	>100
41	3-(2,5-dimethylthiophene)	24
42	tBu	37