Figure 3.

Structural Correlations among Members of the Dehydrogenase Family Involve the Whole Molecular Complexes

(A) Homo-tetramer of human hydroxyisobutyrate dehydrogenase (2i9p, chains A, B, C, and D, blue).

(B) Homo-dimer of 6-phosphogluconate dehydrogenase from E.coli (3fwn, chains A and B, green).

(C) Homo-dimer of 2-dehydropantoate 2-reductase from the proteobacterium Methylococcus capsulatus (3i83, chains A and B, yellow).

(AB) Superposition of (A) and (B), with aligned regions in orange (2i9p) and red (3fwn).

(AC) Superposition of (A) and (C), with aligned regions in orange (2i9p) and red (3i38).

(BC) Superposition of (B) and (C), with aligned regions in orange (3fwn) and red (3i38).