Table 2.
Correlation Between Log-Transformed Lipid and Lipoprotein Measures with CD4 Count, HIV RNA Level and Biomarkers at Baseline: SMART Participants Not Taking ART at Study Entry.
| Correlation Coefficient (p-value) | ||||||||
|---|---|---|---|---|---|---|---|---|
| HDL Measures | HDL-P (nmol/L) | ApoA1 (g/L) | LDL-P (nmol/L) | ApoB (g/L) | CD4 Count (cells/mm3) | HIV RNA (copies/mL) | hsCRP (μg/mL) | IL-6 (pg/mL) |
| HDL-C (mg/dL) | 0.57 (<0.001) | 0.56 (<0.001) | −0.17 (0.007) | −0.11 (0.095) | 0.02 (0.74) | −0.14 (0.026) | −0.20 (0.001) | −0.12 (0.073) |
| HDL-P (nmol/L) | -- | 0.61 (<0.001) | 0.20 (0.002) | 0.28 (<0.001) | 0.01 (0.89) | −0.07 (0.26) | −0.19 (0.003) | −0.35 (<0.001) |
| ApoA1 (g/L) | 0.61 (<0.001) | -- | 0.07 (0.32) | 0.36 (<0.001) | −0.01 (0.86) | −0.15 (0.023) | −0.26 (<0.001) | −0.20 |
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|
LDL Measures
| ||||||||
| LDL-C(mg/dL) | 0.40 (<0.001) | 0.26 (<0.001) | 0.74 (<0.001) | 0.74 (<0.001) | −0.05 (0.43) | −0.09 (0.17) | 0.07 (0.30) | −0.20 (0.001) |
| LDL-P (nmol/L) | 0.20 (0.002) | 0.07 (0.32) | -- | 0.75 (<0.001) | 0.05 (0.39) | 0.01 (0.92) | 0.19 (0.003) | −0.10 (0.12) |
| ApoB (g/L) | 0.28 (<0.001) | 0.36 (<0.001) | 0.75 (<0.001) | -- | 0.01 (0.90) | −0.04 (0.59) | 0.02 (0.78) | −0.12 (0.068) |
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|
VLDL Measures
| ||||||||
| Triglycerides (mg/dL) | 0.02 (0.69) | −0.03 (0.66) | 0.37 (<0.001) | 0.45 (<0.001) | 0.05 (0.43) | 0.09 (0.16) | 0.03 (0.65) | 0.03 (0.59) |
| VLDL-P (nmol/L) | 0.12 (0.049) | 0.00 (0.94) | 0.43 (<0.001) | 0.52 (<0.001) | 0.04 (0.49) | 0.07 (0.29) | 0.02 (0.79) | −0.11 (0.075) |
Lipoprotien particle concentrations, lipid levels and biomarkers were loge, and HIV RNA log10, transformed prior to comparisons. HDL-C and HDL-P = high-density lipoprotein cholesterol and particles, respectively; LDL-C and LDL-P = low-density lipoprotein cholesterol and particles, respectively; VLDL-P = very low-density lipoprotein particles; ApoA1 = apolipoprotein A1; ApoB = apolipoprotein B.