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. Author manuscript; available in PMC: 2013 Mar 27.
Published in final edited form as: Biochemistry. 2012 Mar 16;51(12):2366–2377. doi: 10.1021/bi300050b

Figure 1.

Figure 1

A UBN1 region N-terminal to the previously defined HRD (Hpc2-related Domain) shows modest yet significant sequence homology among UBN1/UBN2 and, to a lesser extent, Hpc2. Sequence conservation is shaded as: red (identical), yellow (highly conserved), cyan (highly conserved among UBN1/UBN2 only), and grey (highly conserved among Hpc2 only). Residue numbers are given along the sequences, with human UBN1 residue numbers also marked on top of the alignment. Triangles are used to label UBN1 residues that are mutationally sensitive (red), or not sensitive (black), for HIRA binding. Sequences are from organisms Hs (homo sapiens), Gg (Gallus gallus), Dr (Danio rerio), Dm (Drosophila Melanogaster), Sc (Saccharomyces cerevisiae), Kl (Kluyveromyces lactis), Ca (Candida albicans), and Sp (Schizosaccharomyces pombe). “yema" stands for yemanuclein-α.