Table 2.

Cox regression (survival) analyses of conversion from mild cognitive impairment to Alzheimer’s disease (31 converters, 99 non-converters). Individual points were identified visually from the center of the most prominently significant clusters of points of inward deformation. The distance of each point from the corresponding point in the template brain, and the volume of the structure (left or right hippocampus or entorhinal cortex) were both included in the same Cox regression model with age, sex, education and intracranial volume. Each Cox regression model is represented in one row with only two variables shown: distance of the point from the corresponding point on the template brain, and the volume of the relevant anatomical structure in which the point was located.

Location	Distance of Point			Volume
	Hazard ratio	95% CI	P =	Hazard ratio	95% CI	P =
CA1, right hippocampus	0.472	0.258, 0.861	0.01	0.224	0.049, 1.028	0.054
CA1, left hippocampus	0.821	0.608, 1.108	0.20	0.226	0.048, 1.055	0.06
Subiculum, right hippocampus	0.472	0.258, 0.861	0.01	0.224	0.049, 1.028	0.054
Subiculum, left hippocampus	0.229	0.108, 0.486	0.0001	0.219	0.057, 0.845	0.03
Entorhinal cortex, right anterior inferiomedial	0.350	0.201, 0.609	0.0002	0.054	0.00, 52.08	0.06
Entorhinal cortex, left anterior inferiomedial	0.518	0.353, 0.760	0.0008	0.016	0.00, 19.68	0.26