Table III.

Role of basophils in blood transfusion.

Basophils: roles and issues in transfusion medicine	References
Anaphylaxis associated with non-haemolytic transfusion reactions (NHTRs):
a. anaphylaxis to IgA;	Sandler, Transf Med Hemother, 2003
b. anaphylaxis to haptoglobin;	Shimada et al., Transfusion, 2002
c. anaphylaxis to blu methylene-treated fresh-frozen plasma.	Gilstad, Curr Opin Hematol, 2003
Febrile non-haemolytic transfusion reactions due to cytokines production	Dewachter et al, Br J Anaesth, 2011
Activation of basophils by BRMs:	Addas-Carvalho et al., Transf Med, 2006
a. cytokines;
b. bacterial products (PAMP, PAR, fMLP, LPS, etc.);	Matsuyama et al., Transf Med, 2005
c. activated complement factors;
d. chemokines.
Passive IgE sensitisation following blood transfusion
Usefulness in diagnosing allergy to blood transfusion:	Johansson et al., Allergy, 2005
a. basophil activation test;
b. flow cytometry of basophil function (intracellular markers).