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. Author manuscript; available in PMC: 2012 Apr 6.
Published in final edited form as: Chem Biol Drug Des. 2010 Nov 29;77(1):39–47. doi: 10.1111/j.1747-0285.2010.01052.x

Figure 6.

Figure 6

Ribbon representation of the p15-EC RNH fragment in the absence (A) or presence (B) of 20 mM Mg2+, and of the HIV-1 RT (C). In (A) and (B), the residues that were perturbed by BHMP07 are highlighted red. In (C), the highlighted p15-EC structure (cyan) was superimposed on the RT structure (PDB 2I5J, p51 subunit (gray) and p66 subunit (lime)). The substrate handle region in p15-EC RNH is marked with a dashed circle, and is located at the domain-interface in RT.