Table 2.

Site specific investigation of the BHMP07 dissociation constants against the p15-EC RNH

RNH fragment residue (RT residue)	Inhibitor dissociation constant, KD (μM)
	No Mg++	+ 20 mM Mg++
Q74 (500)	-	246.4 ± 72.8
Y75 (501)	-	262.4 ± 134.8
A76 (502)	191.9 ± 28.9	311.4 ± 41.5
I79 (505)	211.6 ± 20.1	371.6 ± 60.2
W83a	142.7 ± 35.7	392.0 ± 69.6
K93	193.8 ± 18.3	454.1 ± 150.6
I114 (526)	216.8 ± 38.4	320.9 ± 26.2
V124 (536)	242.5 ± 18.2	-

^aDetected for indole amine signal.